ACCRA, GHANA – On the afternoon of Dec. 26, 2022, Chris Maurice finally capitulated and went to the emergency room at Hospital Clinic de Barcelona, just west of the city’s gothic quarter. For roughly ten months, the 26-year-old CEO of the largest centralized crypto exchange in Africa had ignored many of the symptoms consistent with malaria as he bounced between 21 different countries on the continent, advising heads of state on bitcoin adoption and setting up institutional accounts for his business, Yellow Card.

By the time Maurice was admitted to the intensive care unit, plasmodium parasites had been wreaking havoc on his red blood cells for nearly a year, multiplying in his liver and threatening to shut down many of his major organs, including his kidneys. His face and eyes were yellow from jaundice. As his hemoglobin levels plummeted in response to the intravenous meds administered as treatment, four days of blood transfusions helped save his life.

But to Maurice, his brush with death was simply the price of doing business. Since graduating from Auburn University in Alabama with a finance degree four years ago, he has traded security and stability for a career on the road, all with the goal of fundamentally disrupting Africa’s broken financial system.

“I’ve slept more nights than I can count in the Joburg airport,” Maurice told CNBC on the sidelines of the Africa Bitcoin Conference in Ghana. “I’ve mastered the art of where to go to find chairs with no armrests. I’m...

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